Microbiology Questions-13

Which of the following drugs acts by inhibiting
viral protease, thus preventing final protein
editing?
(A) acyclovir
(B) amprenavir
(C) didanosine
(D) enfuvirtide
(E) zidovudine

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Microbiology Questions-12

Which of the following drugs is the current
drug of choice for treatment of trichinosis
(Trichinella spiralis) infections?
(A) dehydroemetine
(B) diloxanide
(C) mebendazole
(D) metronidazole
(E) praziquantel

Answer Here

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Microbiology Questions-11

Over several years, an 11-year-old student
developed multiple infections caused by organisms
normally of low virulence (Staphylococcus
epidermidis, Aspergillus) and was diagnosed as
having chronic granulomatous disease (CGD).
This immune deficiency is due to which of the
following?
(A) inability of neutrophils to kill bacteria
(B) inability of phagosomes to fuse with
lysosomes
(C) inability of polymorphonuclear leucocytes
to ingest bacteria
(D) loss of complement components
(E) reduced levels of immumoglobulins

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Microbiology Questions-10

10. Severe septic infections caused by bacteriapossessing
capsules often occur following
splenectomy. Which of the following statements
most accurately explains why this medical
complication is able to occur?
(A) The spleen is a source of IgM and IgG
antibodies needed to opsonize encapsulated
bacteria.
(B) The spleen is the main source of stem
cells.
(C) The spleen is uniquely equipped to
process capsular polysaccharides.
(D) The spleen rapidly inactivates many
antimicrobial agents.
(E) The spleen readily metabolizes therapeutic
doses of antibiotics.

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Microbiology Questions-9

9. A 38-year-old sexually-active woman developed
symptoms of lower abdominal pain with
adjacent tenderness. No gram-negative cocci
were observed or isolated. The obligate intracellular
organism causing the infection is
unable to perform which of the following metabolic
functions?
(A) form ATP
(B) form the intracellular, metabolically
active, reticulate body
(C) produce polypeptides
(D) reproduce by binary fission
(E) synthesize DNA gyrase

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Microbiology Questions-8

8. A25-year-old man with acquired immune deficiency
disease (AIDS) has malabsorption,
chronic abdominal pain, low-grade fever, and
nonbloody diarrhea. In fecal smears, large
numbers of oocysts containing four sporozoites
were observed. Which of the following organisms
is most likely the etiological agent?
(A) Cryptosporidium parvum
(B) Entamoeba histolytica
(C) Giardia lamblia
(D) Microsporidia species
(E) Taenia solium

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Microbiology Questions-7

7. Which of the following statements best
describes interferon’s suspected mode of action
in producing resistance to viral infection?
(A) It alters the permeability of the cell
membrane so that viruses cannot enter
the cell.
(B) It stimulates a cell-mediated immunity.
(C) It stimulates humoral immunity.
(D) Its action is related to the synthesis of a
protein that inhibits mRNA function.
(E) Its direct antiviral action is related to
the suppression of messenger RNA
formation.

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Microbiology Questions-6

In February, three patients from a nursing
home in East Dallas develop an abrupt onset of
a febrile upper respiratory tract illness. They
have received no immunizations in the last
year. Culture of the nasopharynx of one patient
shows influenza A virus. To prevent further
cases within the next two weeks, which of the
following should be administered?
(A) acyclovir
(B) amantadine
(C) hyperimmune serum globulin
(D) influenza A vaccine
(E) ribavirin

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Microbiology Questions-3

3. An emaciated prisoner in a New York prison
began coughing up sputum streaked with
blood. Examination of the sputum revealed the
presence of acid-fast bacilli. Which of the following
would be least helpful in establishing a
diagnosis of tuberculosis?
(A) agglutination test for antibodies
(B) niacin production test
(C) nitrate reduction test
(D) rough, non-pigmented colonies
(E) slow growth on Lowenstein-Jensen
medium

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Microbiology Questions-2

 A 10-year-old boy has a bacterial pneumonia.
The etiologic agent had M type-1 protein and
grew on blood agar. The patient’s immune
system appeared incapable of controlling the
infection. Adecrease in which of the following
is most directly related to the immunological
failure?
(A) antibody activity
(B) cytotoxic T-cell function
(C) IL-4 and IL-10 levels
(D) mast cell degranulation
(E) platelet aggregation

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Microbiology Questions-1

Astudent has a genetic defect and cannot produce
the J chain which is important in the structure
of some immunoglobulin molecules.
Which of the following will most likely be
observed in this individual?
(A) a decrease in mature B cells
(B) a decrease in mature T lymphocytes
(C) a decrease in serum IgM
(D) an increase in IgA in the intestine
(E) an increase in serum IgM and decrease
in IgE

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