Biochemistry Question-11

An investigational diabetes treatment involving
a hypoglycemia-inducing drug has been
developed. This drug is designed to inhibit
dipeptidylpeptidase IV (DPP IV) activity and
has been shown to decrease plasma glucose
concentration and pancreatic glucagon secretion.
DPP IV hydrolyzes which of the following
hormones such that its inhibition results in the
observed effects?
(A) glucagon
(B) glucagon-like peptide-1 (GLP-1)
(C) insulin
(D) insulin-like growth factor-I (IGF-I)
(E) pancreatic polypeptide

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Biochemistry-3

An adult man suffered from stable angina pectoris
for 15 years, during which time there was
progressive heart failure and repeated pulmonary
thromboembolism. On his death at age
63, autopsy disclosed enormous cardiomyopathy
(1100 g), cardiac storage of globotriaosylceramide
(11 mg lipid/g wet weight), and
restricted cardiocytes. Which of the following
lipid storage diseases would result in these
clinical findings?
(A) Fabry disease
(B) Gaucher disease
(C) Krabbe disease
(D) Niemann-Pick disease (NPD) type I A
(E) Tay-Sachs disease

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Biochemistry-4

4. An investigational diabetes treatment involving
a hypoglycemia-inducing drug has been
developed. This drug is designed to inhibit
dipeptidylpeptidase IV (DPP IV) activity and
has been shown to decrease plasma glucose
concentration and pancreatic glucagon secretion.
DPP IV hydrolyzes which of the following
hormones such that its inhibition results in the
observed effects?
(A) glucagon
(B) glucagon-like peptide-1 (GLP-1)
(C) insulin
(D) insulin-like growth factor-I (IGF-I)
(E) pancreatic polypeptide

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Biochemistry-1

A deficiency of argininosuccinate synthetase
(ASD) can be suspected in a 24–48-hour-old
neonate with elevated serum ammonia. To discriminate
the fact that the hyperammonemia is
indeed due to ASD and not due to a deficiency
in other urea cycle enzymes, one can assay for
the serum concentration of citrulline and urinary
orotic acid concentration. Which of the
following would best describe the expected
findings?
(A) Both citrulline and orotate levels will be
low.
(B) Citrulline levels will be absent but orotate
will be elevated.
(C) Citrulline levels will be between
100–300 μM and orotate levels will be
elevated.
(D) Citrulline levels will be >1000 μM, orotate
will be near normal.

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