Pharmacology Questions-16

Which of the following drugs is most dangerous
in suicidal overdosage?
(A) bupropion
(B) citalopram
(C) fluoxetine
(D) imipramine
(E) phenelzine


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Pharmacology Questions-15

A26-year-old woman with cerebral palsy complains
of severe pain associated with spasms in
her leg muscles. Which of the following drugs
is used in cerebral palsy to reduce skeletal
muscle spasticity by an action on cholinergic
nerve endings?
(A) baclofen
(B) botulinum toxin
(C) dantrolene
(D) diazepam
(E) tubocurarine

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Pharmacology Questions-14

A78-year-old man has ankle edema, tachycardia,
and shortness of breath on mild exercise.
His blood pressure is 155/98. He has been diagnosed
with hypertension and mild heart failure.
Which of the following regimens is most
appropriate for starting therapy?
(A) captopril plus dobutamine
(B) captopril plus hydralazine
(C) enalapril plus hydrochlorothiazide
(D) furosemide plus spironolactone
(E) losartan plus hydralazine

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Pharmacology Questions-13

Which of the following agents used in combination
therapy for HL has pulmonary fibrosis
as its most serious toxicity?
(A) bleomycin
(B) cisplatin
... (C) doxorubicin
(D) mechlorethamine
(E) vincristine

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Pharmacology Question-8

8. A57-year-old man presents with angina. He uses
1 or 2 nitroglycerin tables sublingually when he
experiences chest pain. Which of the following
drugs may interact to cause serious hypotension
if taken 6 hours or less before the nitrate?
(A) clonidine
(B) diltiazem
(C) metronidazole
(D) phentolamine
(E) sildenafil

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Pharmacology Question-10

10. Which of the following beta-lactam drugs has
good activity against beta-lactamase-producing
organisms and penetrates readily into cerebrospinal
fluid?
(A) amoxicillin
(B) cefazolin
(C) clavulanic acid
(D) imipenem
(E) ticarcillin

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Pharmacology Question-9

9. Diltiazem as used in angina pectoris has several
beneficial actions that contribute to the
prevention of the anginal symptoms. Which of
the following actions is detrimental in angina?
(A) reduced arterial blood pressure
(B) increased diastolic heart size
(C) reduced systolic myocardial fiber tension
(D) bradycardia
(E) slowed AV conduction

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Pharmacology Question-7

A 50-year-old man presents with a blood pressure
of 160/100. He is to be started on
hydrochlorothiazide. Which of the following is a
common adverse effect of hydrochlorothiazide?
(A) atrioventricular (AV) blockade
(B) constipation
(C) drug-induced lupus erythematosus
(D) potassium wasting
(E) tachycardia

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Pharmacology Question-6

6. Mifepristone has antagonist action at which of
the following receptors?
(A) beta adrenoceptors
(B) dopamine receptors
(C) insulin receptors
(D) low-density lipoprotein receptors
(E) progesterone receptors

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Pharmacology Question-5

5. The location of the lesion in Horner syndrome
(either preganglionic or postganglionic) can be
determined by the use of certain sympathomimetics.
Which of the following agents
would distinguish between a preganglionic
versus a postganglionic lesion?
(A) amphetamine
(B) atenolol
(C) epinephrine
(D) isoproterenol
(E) phenylephrine

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Pharmacology Question-4

Which of the following drugs inhibit osteoclastic
activity more than osteoblastic activity
and have been beneficial in osteoporosis, hypercalcemia
of malignancy, and Paget disease?
(A) alendronate
(B) calcitonin
(C) fluoride
(D) parathyroid hormone
(E) vitamin D

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Pharmacology Question-2

Which of the following receptor types is associated
with the most rapid response time?
(A) G-protein-coupled receptors (e.g., muscarinic
receptors)
(B) ion channel receptors (e.g., nicotinic
receptors)
(C) Jak-STAT receptors (e.g., for cytokines)
(D) steroid receptors (e.g., for corticosteroids)
(E) transmembrane enzyme receptors (e.g.,
for insulin)

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Pharmacology Question-3

 Which of the following responses to sympathetic
nerve discharge is mediated at the effector
cell by acetylcholine?
(A) decreased blood flow in the skin
(B) increased blood fatty acids
(C) increased blood glucose
(D) increased heart rate
(E) increased sweating

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Pharmacology Question-1

Which of the following drugs acts primarily
on an intracellular receptor?
(A) abciximab
(B) dexamethasone
(C) insulin
(D) propranolol
(E) salmeterol

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