Biochemistry-4

4. An investigational diabetes treatment involving
a hypoglycemia-inducing drug has been
developed. This drug is designed to inhibit
dipeptidylpeptidase IV (DPP IV) activity and
has been shown to decrease plasma glucose
concentration and pancreatic glucagon secretion.
DPP IV hydrolyzes which of the following
hormones such that its inhibition results in the
observed effects?
(A) glucagon
(B) glucagon-like peptide-1 (GLP-1)
(C) insulin
(D) insulin-like growth factor-I (IGF-I)
(E) pancreatic polypeptide

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