Pharmacology Answers-15

(B) Botulinum toxin acts on cholinergic nerve
endings (including skeletal muscle motor nerve
endings) to reduce acetylcholine release.
Baclofen (A) acts in the CNS to activate GABAB
receptors; some sedation may result. Dantrolene
(C) acts within the skeletal muscle cell to
reduce calcium release from the sarcoplasmic
reticulum; reduction of muscle spasm results
without central nervous system depression.
Diazepam (choice D) facilitates GABAergic
transmission in the brain and spinal cord; it
does not act on cholinergic transmission.
Tubocurarine (choice E) causes profound
skeletal muscle paralysis by blocking acetylcholine
receptors in the neuromuscular junction.
Unlike the other drugs listed, it is not
useful in cerebral palsy.

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